|
Symbol Name ID |
Ppargc1a
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha MGI:1342774 |
| Darker colors indicate more annotations |
| Human Phenotypes | Hyposmia |
Dysphagia |
Spasticity |
Fatigable weakness of bulbar muscles |
Fatigable weakness of swallowing muscles |
Fatigable weakness of respiratory muscles |
Gliosis |
Motor neuron atrophy |
Amyotrophic lateral sclerosis |
Cerebellar atrophy |
Neurodegeneration |
Neuronal loss in central nervous system |
Gait ataxia |
Bradykinesia |
Chorea |
Fasciculations |
Tremor |
Paralysis |
Babinski sign |
Dysarthria |
Language impairment |
Depression |
Emotional lability |
Anxiety |
Panic attack |
Hallucinations |
Atypical behavior |
Apathy |
Reduced social reciprocity |
Personality changes |
Impulsivity |
Agitation |
Restless legs |
Cognitive impairment |
Dementia |
Frontal lobe dementia |
Frontotemporal dementia |
Short attention span |
Sleep abnormality |
Insomnia |
Hyperreflexia |
Jaw hyperreflexia |
Dyskinesia |
Dystonia |
Gait imbalance |
Postural instability |
Seizure |
Abnormal autonomic nervous system physiology |
| Disease(s) Associated with PPARGC1A | ||||||||||||||||||||||||||||||||||||||||||||||||
| amyotrophic lateral sclerosis | ||||||||||||||||||||||||||||||||||||||||||||||||
| Huntington's disease | ||||||||||||||||||||||||||||||||||||||||||||||||
| Parkinson's disease |
| Mouse Phenotypes | myoclonus |
abnormal brainstem morphology |
abnormal substantia nigra morphology |
abnormal basal ganglion morphology |
abnormal hippocampus morphology |
abnormal cerebral cortex morphology |
abnormal cerebellum morphology |
gliosis |
abnormal neuron morphology |
decreased dopaminergic neuron number |
short photoreceptor inner segment |
short photoreceptor outer segment |
retina photoreceptor degeneration |
neurodegeneration |
spongiform encephalopathy |
|
| Availability | Mouse Genotype | |||||||||||||||
| Ppargc1atm1Brsp/Ppargc1atm1Brsp | ||||||||||||||||
| Ppargc1atm1Dpk/Ppargc1atm1Dpk | ||||||||||||||||
| Ppargc1atm1Brsp/Ppargc1a+ | ||||||||||||||||
| Ppargc1atm2.1Brsp/Ppargc1atm2.1Brsp (conditional) | ||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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